Dynamics of longitudinal dentate gyrus axons associated with seizure

Key points Axon collaterals of DG granule neurons project towards neighbouring cell layer Longitudinal axons in the DG-DG circuit possess denser synapses than transverse DG-CA3 The size varicosities longitudinal axons, but not ones, is regulated by seizures as measured behaviourally Varicosity can be a symptomatic marker DG-related brain diseases Abstract hippocampus network has captured attention neuroscientists model for understanding cognition and behaviour. Previously, we have identified interlamellar, namely longitudinal, between CA1 pyramidal analogous to recurrent connections CA3 neurons. Currently it unknown whether are present how they associated with behavioural symptoms seizure. We found projections from cells extending layers. These more numerous thinner suggesting heavy synaptic formation along axis. Furthermore, behaviourally. results suggest that dynamics diseases.